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Computer Science and Software Engineering Capstone Presentations

Summer Quarter

August 21, 2020

Timothy Lawton

"VIA-QMI: Abstract"

(UWB CSS Faculty Research)

Faculty Advisor: Dr. Wooyoung Kim

Abstract

This project is a continuation of the Visualized Data Analytic Tool for Quantitative Multiplex Co-Immunoprecipitation (VIA-QMI) to assist with developing cancer treatments in the field of immunotherapy. The Seattle Children's Hospital SEPS lab, created by Dr. Stephen Smith, uses a novel approach to diagnosing and treating cellular diseases by analyzing abnormal protein to protein interactions. Dr. Smith's Quantitative Multiplex Co-Immunoprecipitation (QMI) platform generates the necessary data for engineering T-Cells that allow for patient immune systems to fight abnormal cells. This treatment against cellular diseases does not destroy healthy cells within a patient's body, in contrast to other cancer treatments such as chemotherapy and radiation therapy. The existing QMI platform lacks analysis visualization, requires multiple software tools, and has a limit to the number of experiments that can be simultaneously conducted. The result of this project is the creation of a graphical user interface (GUI) for the QMI process that allows the user to consolidate several analysis tools into one intuitive program. The result aims to be a faster, user friendly program that is not restricted to the limitations of 8 parallel experiments. My contribution for the project entails the updating of the GUI for easier readability, modularization of hardcoded program classes, and creating project documentation. Due to time restrictions, I was limited to the deprecated tools of the existing project in adapting the software logic into reusable code for greater program flexibility. With an updated framework, this project has the potential to streamline genetic cellular disease research to produce less harmful patient treatments.

Updated August 20, 2020, 00:55